In 1979, Dr. Pushpa M. Bhargava and E.S.R. Reddy of the Regional Research Laboratory in Hyderabad identified seminal plasmin, a protein in bull seminal fluid. This protein exhibits potent antimicrobial properties, effectively inhibiting a broad spectrum of microorganisms, including yeast. Further studies revealed that seminal plasmin can inhibit bacterial RNA polymerase, suggesting a mechanism for its antimicrobial activity. citeturn0search1 This discovery has contributed to the understanding of natural antimicrobial agents and their potential applications in combating infections.